Platelet-Rich Plasma (PRP) for Skin Rejuvenation: What Patients Should Know

Platelet-rich plasma (PRP) therapy—sometimes known as the “vampire facial”—has attracted widespread attention for its potential to rejuvenate aging skin. Although PRP has promising early results for fine lines, dullness, and acne scars, it is still considered an emerging cosmetic treatment with ongoing research.

At Advanced Dermatology Care, our providers offer PRP as part of our Cosmetic Dermatology Services when appropriate, always prioritizing patient safety and evidence-based care.

What Is PRP?

PRP is a concentrated component of your own blood that contains platelets—cells responsible for healing and tissue repair. During PRP treatment, your blood is processed so that these platelets can be applied to the skin.

How PRP Is Prepared

PRP involves a simple three-step process:

Blood Draw

About 2–4 tablespoons of your blood is taken from your arm.

Centrifugation

The vial is placed in a centrifuge—a device that spins rapidly to separate blood components.
One layer contains a high concentration of platelets.

Application or Injection

Your dermatologist applies or injects the platelet-rich portion into targeted areas of the face or scalp.
This may be done using:

  • A syringe
  • Microneedling, which creates tiny channels in the skin

(Learn more about microneedling on our Microneedling Results & Expectations page once published.)

The entire appointment typically lasts 45–60 minutes.

What Can PRP Improve?

While PRP is still undergoing clinical evaluation, many patients report improvement in:

  • Fine lines and early wrinkles
  • Mild skin laxity
  • Deep facial creases
  • Dull or uneven complexion
  • Acne scars

Some dermatologists also combine PRP with dermal fillers for more immediate plumping or with RF microneedling to enhance collagen stimulation.

Downtime

Most patients experience little to no downtime beyond minor redness or swelling.

How Strong Is the Scientific Evidence?

Despite its popularity, PRP for cosmetic rejuvenation remains understudied. The U.S. FDA categorizes PRP as a medical device, not a drug—meaning large-scale clinical trials are not required.

As a result, dermatologists still seek answers about PRP, including:

  • Why some patients respond strongly while others do not
  • How many treatments are ideal
  • Optimal spacing between sessions
  • Best depth, device, and injection technique
  • Ideal platelet concentration
  • Long-term safety data

Early evidence is promising, but not definitive.

Is PRP Safe?

When performed by a qualified medical professional, PRP appears to be very safe. Side effects are typically mild and may include:

  • Temporary redness
  • Mild swelling
  • Bruising or tenderness

The biggest risk is improper blood handling.

To ensure safety:

  • Sterile technique must be used
  • Your own blood must be carefully tracked and reinjected back into you
  • Equipment must meet medical-grade standards

This is why PRP should not be performed in non-medical spas or by unlicensed providers.
For safe cosmetic treatment, see our board-certified dermatology team.

How Many PRP Sessions Do You Need?

Most patients who respond well to PRP typically need:

  • 3 or more treatments
  • Spaced 4–6 weeks apart

This means returning for repeated treatments, including blood draws and reinjections.

To give patients immediate visible improvement, some dermatologists combine PRP with hyaluronic acid fillers during the same visit.

When Will You See Results?

Results are gradual because PRP stimulates the body’s natural healing processes.

Expected timeline:

  • Initial improvement: a few weeks
  • Full results: several months
  • Duration: Results may last up to 18 months depending on skin condition and lifestyle

Who Is Not a Candidate for PRP Rejuvenation?

PRP is not recommended for individuals with conditions affecting blood or platelet quality, including:

  • Hepatitis C
  • HIV or AIDS
  • Blood cancers (leukemia, lymphoma)
  • Cardiovascular disease requiring blood thinners
  • Active skin cancer in the treatment area

These conditions may prevent PRP from working effectively.

If you are unsure whether PRP is right for you, schedule a consultation via our
New Patients page.

How Much Does PRP Cost?

Because PRP is cosmetic, insurance does not cover it.

Costs generally range from $250 to $1,500 per session, depending on:

  • Provider experience
  • Geographic region
  • Whether PRP is paired with fillers or microneedling
  • Number of treatment areas

Our team can provide a personalized estimate during your consultation.

Is PRP Right for You?

PRP may be worth considering if you want to improve mild signs of aging or acne scars using a minimally invasive, low-downtime treatment.

A board-certified dermatologist can:

  • Evaluate your skin
  • Explain whether PRP is likely to help your concerns
  • Recommend proven alternatives if PRP is not ideal
  • Develop a personalized cosmetic plan

At Advanced Dermatology Care, our dermatology professionals specialize in safe, evidence-based cosmetic procedures and will help determine whether PRP aligns with your goals.

Learn more about our cosmetic services or schedule a consultation:
➡ Cosmetic Dermatology Services
➡ New Patients